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1994-10-25
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Document 2297
DOCN M94A2297
TI HIV-1, HTLV-1, and tuberculosis among intravenous drug users in Rio de
Janeiro, Brazil.
DT 9412
AU Kritski A; Carvalho AC; Schechter M; Vieira MA; Oliveira J;
Werneck-Barroso E; Ferreira O; Novor P; Hearst N; Nucleo de Pesquisa em
Tuberculose, Servico de Pneumologia do; Hospital Univ. Clementino Fraga
Filho, Universidade Federal do; Rio de Janeiro, Brazil.
SO Int Conf AIDS. 1994 Aug 7-12;10(1):336 (abstract no. PC0278). Unique
Identifier : AIDSLINE ICA10/94370278
AB OBJECTIVE: To evaluate the association between Tuberculosis infection
and TB disease and HIV-1 and/or HTLV-1 infection among IVDUs who
attended a Drug Treatment Center (NEPAD/UFRJ) in Brazil. METHODS: From
July, 1991 to October, 1992, 80 IVDUs (68 male) were consecutively
referred to Chest Service by NEPAD/UFRJ. After written consent, they
were examined, asked to answer a questionnaire, and tested for HIV and
HTLV-1 infection. RESULTS: The mean age was 28.8 SD +/- 6.4 yrs. HIV-1
infection and HTLV-1 occurred in 25 (31.2%) and 22 (27.5%) IVDUs,
respectively; 12 (15.0%) were infected by both. In the last 3 years, 70
(93.3%) of IVDUs have used cocaine; 62 (82.6%) marijuana. Twenty-one
(26.3%) were homosexual men and 4 (5.3%) reported prostitution in the
last 6 months. Among HIV-1 seronegative IVDUs, a positive PPD skin test
(> 10mm) was observed in 69.3% (10/46); among HIV-1 seropositives, 40%
(8/20) (using > 5mm). Fourteen (17.5%) IVDUs had respiratory symptoms; 3
(3.7%) had culture-proven TB (all with HIV-1 and 2 with HTLV-1
infection). Two (2.5%) mentioned anti-TB treatment in the past, and 11
(13.7%) reported TB in the last 3 years within the family. The
occurrence of positive PPD skin test or TB disease was not associated
with the following variables: race, sex, schooling less than 4 years,
family monthly income less than US $1,000, alcoholism (using CAGE test),
severity of alcoholism (using SAAD test) and duration of the use of
drugs. But significant association was found between HIV-1, HTLV-1/2
infection, and the occurrence of negative PPD skin test, TB disease and
severity of alcoholism. CONCLUSIONS: In Rio de Janeiro, the high rate of
HIV-1, HTLV-1 infection, and TB infection among IVDUs highlights the
possible burden of this association. This information must be taken into
account when these individuals are treated in any health care setting,
related or not to drug addiction.
DE Adult AIDS-Related Opportunistic Infections/*EPIDEMIOLOGY/TRANSMISSION
Brazil/EPIDEMIOLOGY *Developing Countries Female Human HIV
Infections/*EPIDEMIOLOGY/TRANSMISSION *HIV-1 *HTLV-I HTLV-I
Infections/*EPIDEMIOLOGY/TRANSMISSION Male Mass Screening Risk
Factors Substance Abuse Treatment Centers Substance Abuse,
Intravenous/COMPLICATIONS/*EPIDEMIOLOGY Tuberculosis,
Pulmonary/*EPIDEMIOLOGY/TRANSMISSION Urban Population/*STATISTICS &
NUMER DATA MEETING ABSTRACT
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).